When on immuno suppressors, such as the Simponi I am on, you have to be VERY careful about vaccines. Your immune system is compromised so the side effects can be much worse than you would normally experience. I am going through that at this moment. NOT fun. You also should take absolutely no live vaccines. I don't know the full list of these, but I do know one of the most common being the flu vaccine which is inhaled. I have always had a bad time with any flu vaccine so it is one I always avoid as a rule.
Another thing with vaccines to consider even if you are healthy, but have a family history of immuno disorders, is that they can actually trigger the immuno reaction. This is also my situation, or at least it is suspected to be. I was a healthy, active person before taking the Anthrax vaccine when I was in the army. I had a very strong reaction almost immediately after taking it, but 2 weeks or so after my 2nd round is when I developed psoriasis.
I do believe personally that vaccines have benefited the human race. Many diseases that were killers in the not so distant past are no longer the universal threat they were. I also believe that we have managed to systematically ruin our immune systems by trying to manipulate them. Not only with vaccines, but with the barrage of anti-germ products we are inundated with. I don't know what the answer is except to be informed. Just like any medical decision weigh the goods and bads. I decided the benefits outweighed the negatives this time and took the TDAP. Yes I am pretty miserable, but whooping cough would kill me with my compromised immune system. Hopefully the nausea, vomiting, diarriah, fever and pain will pass soon. In the meantime I am catching up on all the chic flicks on netflix.